Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species.
نویسندگان
چکیده
Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.
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ورودعنوان ژورنال:
- Chemical communications
دوره 52 10 شماره
صفحات -
تاریخ انتشار 2016